Serum Paraoxonase Activity and Genotype Distribution in Japanese Patients with Diabetes Mellitus.

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  • SAKAI Takenori
    The Third Department of Internal Medicine, Ehime University School of Medicine
  • MATSUURA Bunzou
    The Third Department of Internal Medicine, Ehime University School of Medicine
  • ONJI Morikazu
    The Third Department of Internal Medicine, Ehime University School of Medicine

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  • Serum Paraoxonase Activity and Genotype

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Abstract

We investigated the serum paraoxonase (PON) activity and genotype distribution in 139 patients with non-insulin-dependent diabetes mellitus and in 240 control subjects in a Japanese population. There were no significant differences in PON genotype frequencies between the diabetic and control subjects, but the PON activity was significantly less in diabetic subjects (p<0.01). PON activity was significantly related to levels of total cholesterol and high density lipoprotein (HDL) cholesterol in the control subjects, but not in the diabetic subjects. In diabetic subjects with the genotype A A, the mean maximum intimal-medial thickness (IMT) of the carotid artery was significantly greater than in subjects with genotype AB or BB. PON may play an important role in the development of atherosclerosis associated with diabetes mellitus.<br>(Internal Medicine 37: 581-584, 1998)

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  • Internal Medicine

    Internal Medicine 37 (7), 581-584, 1998

    The Japanese Society of Internal Medicine

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