Steroid-Responsive Limbic Encephalitis

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  • WATANABE Yasuhiro
    Department of Neurology, Matsue Red Cross Hospital Division of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University
  • SHIMIZU Yasutaka
    Department of Neurology, Matsue Red Cross Hospital
  • Ooi Shinji
    Department of Internal Medicine, Matsue Red Cross Hospital
  • TANAKA Keiko
    Department of Neurology, Brain Research Institute, Niigata University
  • INUZUKA Takashi
    Department of Geriatrics and Neurology, School of Medicine, Gifu University
  • NAKASHIMA Kenji
    Division of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University

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Description

A 71-year-old man presented with gradually progressing cognitive decline following acute febrile exanthematous disorder. The MRI showed an abnormality in the bilateral limbic systems. An elevation of cerebrospinal fluid (CSF) protein with lymphocyte pleocytosis was noted. Immunoblot of the CSF revealed the presence of anti-white matter antibodies that mainly recognized astrocytes. Intravenous steroid followed by oral steroid reduced the symptoms to a remarkable degree. The patient has now been successfully sustained with steroid for more than two years. We considered that this case is classified as non-paraneoplastic limbic encephalitis, and acquired autoimmunity played a major role in the pathogenesis of this case.<br>(Internal Medicine 42: 428-432, 2003)

Journal

  • Internal Medicine

    Internal Medicine 42 (5), 428-432, 2003

    The Japanese Society of Internal Medicine

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