Fatty Acid Composition of Phospholipids in Human Serum Lipoprotein Fractions

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  • Fatty Acid Composition of Phospholipids

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Abstract

The major fatty acids of sphingomyelin in human serum are palmitic (16 : 0) and nervonic (24 : 1) acids. There was a marked difference in distribution of fatty acids between lipoprotein fractions in normal subjects. The concentration of 24 : 1 and the other long chain fatty acids with carbon chain length no less than 22 was significantly higher in a fraction containing high density lipoproteins (HDL) than in another fraction containing low and very low density lipoproteins (LDL). The LDL fraction was rich in 16 : 0. The difference in fatty acid composition of sphingomyelin between these two lipoprotein fractions was not marked in cases of hyperlipidemia, mostly because of a decrease in 24 : 1 in HDL fraction. There was a considerable increase in concentration of behenic acid (22 : 0) in HDL fraction in some cases of hyperlipidemia. LDL fraction seems to be more strict in selecting molecular species of sphingomyelin than HDL. The fatty acid composition of phosphatidylcholine (lecithin) was essentially the same for HDL and LDL fractions.

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