Studies on the Diagnostic Significance of Serum Carboxypeptidase A Activity in Diabetes Mellitus

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  • FUJII Satoru
    The Second Department of Internal Medicine, Osaka City University Medical School
  • YAMAGATA Shigenori
    The Second Department of Internal Medicine, Osaka City University Medical School
  • TANAKA Koshiro
    The Second Department of Internal Medicine, Osaka City University Medical School
  • WADA Masahisa
    The Second Department of Internal Medicine, Osaka City University Medical School
  • AKAI Toshihiro
    Central Laboratory for Clinical Investigation Osaka City University Medical School

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  • Studies on the Diagnostic Significance

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Serum carboxypeptidase A activity (CPase) was measured using carbonaphthoxy-1-phenylalanine as the substrate in various types of diabetes mellitus and the clinical implications of CPase in relation to pancreatic disorders were also discussed. Remarkably low level of CPase was observed in diabetics complicated with pancreatic cancer or chronic pancreatitis (pancreatic diabetics). In growth-onset type and maturity-onset type diabetics (primary diabetics), no remarkable decrease was found in CPase activity, if they were under good control. Very low CPase activity, however, was frequently found in primary diabetics with duration longer than 15 years. Abnormality of pancreatic uptake of 75Se-selenomethionine and/or some degrees of dysfunction in pancreozymin-serection test were found in diabetics with low CPase level, especially in pancreatic diabetics. These results suggest that the determination of CPase is a useful screening method for detecting pancreatic disorders in patients with diabetes mellitus.

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