A Case of Atransferrinemia and 35 Cases of Hypotransferrinemia as Detected by Radioassay of Total Iron-binding Capacity of the Serum

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  • Saito Hiroshi
    Department of Radiology, and Department of Internal Medicine,Nagoya University School of Medicine
  • KATO Yoshiaki
    Department of Radiology, and Department of Internal Medicine,Nagoya University School of Medicine
  • SUZUKI Takashi
    Department of Radiology, and Department of Internal Medicine,Nagoya University School of Medicine
  • KATO Hajime
    Department of Radiology, and Department of Internal Medicine,Nagoya University School of Medicine

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  • Case of Atransferrinemia and 35 Cases o

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Total iron-binding capacity (TIBC) of the serum was determined in 600 patients by the radioassay method devised by Saito. Fifty-four μg/dl of TIBC, which is as low as that of previously reported cases of congenital atransferrinemia, was found in a patient with marked hypoproteinemia probably due to protein losing enteropathy as shown by a high plasma RISA disappearance rate of 41 percent per day. The patient was diagnosed as having secondary atransferrinemia on the bases of hematological findings, iron metabolism and other tests. Thirty-five of 600 patients whose serum TIBC levels were determined by radioassay had low TIBC level below 200 μg/dl. Twenty-one of the 35 (60%) had blood diseases, 13 (37%) had malignancies and 7 (20%) had diseases of digestive organs. TIBC was markedly increased in iron deficiency anemia, while it was normal or decreased in other diseases. TIBC radioassay is a simple, highly accurate and efficient method of measuring transferrin.

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