Hyporeninemic Hypoaldosteronism Complicating Polycythemia Vera

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  • NISHINO Tomokazu
    The Department of Internal Medicine, Hokuriku Hospital the Second Department of Internal Medicine,School of Medicine, University of Kanazawa
  • IMURA Masaru
    The Department of Internal Medicine, Hokuriku Hospital the Second Department of Internal Medicine,School of Medicine, University of Kanazawa
  • MORIMOTO Shinpei
    The Department of Internal Medicine, Hokuriku Hospital the Second Department of Internal Medicine,School of Medicine, University of Kanazawa
  • TAKEDA Ryoyu
    The Department of Internal Medicine, Hokuriku Hospital the Second Department of Internal Medicine,School of Medicine, University of Kanazawa

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  • Hyporeninemic Hypoaldosteronism Complic

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A 58-year-old man with recurrent attacks of cerebrovascular accidents associated with polycythemia vera and hyperkalemia with a sodium losing tendency during dietary sodium restriction is described. The endocrinological studies revealed that the hyperkalemia primarily resulted from the selective deficiency of aldosterone associated with hyporeninemia. The failure to correct the hyporeninemic hypoaldosteronism despite the definite improvements in the hematological findings during busulfan therapy seems to suggest a coincidental occurrence of polycythemia vera and hyporeninemic hypoaldosteronism.

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