Correlation of Plasma Free Thyroxine Levels with Insulin Sensitivity and Metabolic Clearance Rate of Insulin in Patients with Hyperthyroid Graves' Disease.
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- OHGUNI Satoshi
- the First Division, Department of Medicine, Shimane Medical University
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- NOTSU Kazumi
- the First Division, Department of Medicine, Shimane Medical University
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- KATO Yuzuru
- the First Division, Department of Medicine, Shimane Medical University
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説明
Insulin sensitivity, metabolic clearance rate of insulin (MCR-I) and basal posthepatic insulin delivery rate (BIDR) were investigated by means of euglycemic clamp technique in 8 normal subjects and 8 patients with hyperthyroid Graves' disease. The mean (±SD) steady-state glucose infusion rate (SSGIR) was lower in hyperthyroid Graves' patients than in normal subjects (228.9±57.0 vs. 290.9±49.4 mg/m2/min, p<0.05). Both MCR-I and BIDR were higher in hyperthyroid Graves' patients than in normal subjects (1162.9±517.1 vs. 463.5±103.9 ml/m2/min, p<0.005; 17.7±12.6 vs. 3.6±0.9 mU/m2/min, p<0.01, respectively). Plasma free T4 levels showed a close correlation with MCR-I (r=0.77, p<0.05) and BIDR (r=0.81, p<0.05), respectively, in Graves' patients. These findings indicate that hyperthyroidism is characterized by not only a decrease in insulin sensitivity, but also an increase in basal insulin secretion and the metabolic clearance rate of insulin, which are correlated with plasma free T4 levels.<br>(Internal Medicine 34: 339-341, 1995)
収録刊行物
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- Internal Medicine
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Internal Medicine 34 (5), 339-341, 1995
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679844084224
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- NII論文ID
- 10006803667
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- NII書誌ID
- AA10827774
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- COI
- 1:STN:280:ByqA2srjs1A%3D
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- ISSN
- 13497235
- 09182918
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- PubMed
- 7647398
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
