Relationship between the Serum IgA/C3 Ratio and the Progression of IgA Nephropathy
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- KOMATSU Hiroyuki
- First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
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- FUJIMOTO Shouichi
- First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
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- HARA Seiichiro
- First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
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- SATO Yuji
- First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
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- YAMADA Kazuhiro
- First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
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- ETO Tanenao
- First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
書誌事項
- タイトル別名
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- Relationship between Serum IgA/C3 Ratio and Progression of IgA Nephropathy
この論文をさがす
説明
Objective The serum IgA/C3 ratio might be considered to serve as a diagnostic marker for patients with IgA nephropathy (IgAN), but its value as a marker of the severity of histological lesions or prognosis is unknown.<BR> Methods We studied the serum IgA/C3 ratio, using standardized reference material, in 86 patients with IgAN and in 32 with non-IgAN. The patients with IgAN were divided according to the severity of histological lesions (mild IgAN, n=29 and severe IgAN, n=57) based on Japanese clinical guidelines.<BR> Results The serum IgA level was significantly higher, while its C3 level was lower in patients with severe IgAN compared to those with non-IgAN. However, these levels were not different between patients with mild IgAN and non-IgAN. In contrast, the serum IgA/C3 ratio obviously differed among the three groups (2.47±0.96 vs. 3.63±1.44 vs. 4.72±1.86; p<0.01, ANOVA). Kaplan-Meier analysis of the patients with IgAN classified according to the mean serum IgA/C3 ratio revealed that the group with high serum IgA/C3 (4.5 and above) had a significantly poorer renal outcome (p<0.05, log-rank test), since the cumulative renal survival rate at 5 years was 84.4% vs. 100%. The ratio (%) of patients with severe IgAN in whom hematuria disappeared, was significantly higher in the low, than in the high serum IgA/C3 group (41.9% vs. 15.4%; p<0.05, t-test).<BR> Conclusion The serum IgA/C3 ratio appears to reflect the histological severity of IgAN and could serve as a marker of the progression of IgAN.
収録刊行物
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- Internal Medicine
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Internal Medicine 43 (11), 1023-1028, 2004
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679844100224
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- NII論文ID
- 10014043122
- 10014043062
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- NII書誌ID
- AA10827774
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- COI
- 1:CAS:528:DC%2BD2MXjs1yltA%3D%3D
- 1:STN:280:DC%2BD2cnjtl2rsg%3D%3D
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- ISSN
- 13497235
- 09182918
- http://id.crossref.org/issn/09182918
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- HANDLE
- 10458/2065
- 10458/00010506
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- NDL書誌ID
- 7161810
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- Web Site
- https://miyazaki-u.repo.nii.ac.jp/records/1370
- https://miyazaki-u.repo.nii.ac.jp/records/6655
- http://id.ndl.go.jp/bib/7161810
- https://ndlsearch.ndl.go.jp/books/R000000004-I7161810
- http://www.jstage.jst.go.jp/article/internalmedicine/43/11/43_11_1023/_pdf
- http://www.jstage.jst.go.jp/article/internalmedicine/43/11/43_11_1011/_pdf
- https://search.jamas.or.jp/link/ui/2005118697
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可