Clinical Significance of Anti-CCP Antibodies in Rheumatoid Arthritis
-
- MIMORI Tsuneyo
- Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine
この論文をさがす
抄録
A number of novel autoantibodies have been recently described in rheumatoid arthritis (RA), and their clinical significance and possible pathogenic roles have been discussed. In particular, new autoantibodies to citrullinated proteins such as filaggrin and its circular form (cyclic citrullinated peptide: CCP) are especially noteworthy because of their high sensitivity and high specificity. There are many studies that anti-CCP antibodies may serve as a powerful serologic marker for early diagnosis of RA and prognostic prediction of joint destruction. Anti-citrullinated protein antibodies are locally produced in RA joints, and citrullinated proteins (most are fibrins) are localized in RA synovial tissue. This finding strongly suggests a possibility that local citrullination of intraarticular proteins might be the initial event leading to autoantibody production in RA. Genetic factors such as a gene polymorphism of the citrullinating enzyme, PADI, might be associated with the breakage of self-tolerance and induction of autoimmunity against citrullinated proteins.
収録刊行物
-
- Internal Medicine
-
Internal Medicine 44 (11), 1122-1126, 2005
一般社団法人 日本内科学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679844235136
-
- NII論文ID
- 10016885856
-
- NII書誌ID
- AA10827774
-
- COI
- 1:STN:280:DC%2BD2MnmvFCgtg%3D%3D
-
- ISSN
- 13497235
- 09182918
-
- NDL書誌ID
- 7716054
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可