Malignant Fibrous Histiocytoma of Soft Tissue Producing Granulocyte Colony-Stimulating Factor.

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  • MAYUMI Eriko
    the Department of Internal Medicine, Nipponkokan Fukuyama Hospital
  • OKUNO Tetsuji
    the Department of Internal Medicine, Nipponkokan Fukuyama Hospital
  • OGAWA Tetsuo
    the Department of Internal Medicine, Nipponkokan Fukuyama Hospital
  • KURATA Kayoko
    the Department of Internal Medicine, Nipponkokan Fukuyama Hospital
  • ISHIOKA Hidehiko
    the Department of Internal Medicine, Nipponkokan Fukuyama Hospital
  • HAMAMOTO Hiromi
    the Department of Internal Medicine, Nipponkokan Fukuyama Hospital
  • ISHIKI Kuniharu
    the Department of Internal Medicine, Nipponkokan Fukuyama Hospital
  • MAGA Toshiro
    the Department of Internal Medicine, Nipponkokan Fukuyama Hospital
  • OKAMOTO Tsuyoshi
    the Department of Internal Medicine, Nipponkokan Fukuyama Hospital
  • YOSHIDA Tomowo
    the Department of Internal Medicine, Nipponkokan Fukuyama Hospital
  • OGURA Yasuharu
    the Department of Clinical Pathology, Nipponkokan Fukuyama Hospital

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We treated a rare case of malignant fibrous histiocytoma (MFH) of soft tissue that produced granulocyte colonystimulating factor (G-CSF). The patient, an 80-year-old woman, was admitted because of a feeling of abdominal fullness and leg edema. An elastic, hard, tender tumor was palpated in the right thigh. Histopathological examinations of the tumor revealed atypical and prominent pleomorphic spindle-shaped cells with funicular arrangement, which were compatible with the diagnosis of MFH. Prominent leukocytosis (up to 84, 300/μl), a high serum G-CSF concentration (82 pg/ml) and positive immunohistochemical staining of the tumor tissue for G-CSF indicated that G-CSF was produced by the MFH.<br>(Internal Medicine 40: 536-540, 2001)

収録刊行物

  • Internal Medicine

    Internal Medicine 40 (6), 536-540, 2001

    一般社団法人 日本内科学会

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