Prediction of the Development of Hepato-Cellular-Carcinoma in Patients with Liver Cirrhosis by the Serial Determinations of Serum Alpha-L-fucosidase Activity.
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- ISHIZUKA Hideo
- Toubu Chiiki Hospital The Third Department of Internal Medicine, Nihon University
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- NAKAYAMA Tomoki
- The Third Department of Internal Medicine, Nihon University
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- MATSUOKA Shunichi
- The Third Department of Internal Medicine, Nihon University
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- GOTOH Iori
- The Third Department of Internal Medicine, Nihon University
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- OGAWA Masahiro
- The Third Department of Internal Medicine, Nihon University
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- SUZUKI Kazutomo
- The Third Department of Internal Medicine, Nihon University
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- TANAKA Naohide
- The Third Department of Internal Medicine, Nihon University
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- TSUBAKI Kouji
- The Third Department of Internal Medicine, Nihon University
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- OHKUBO Hitoshi
- The Third Department of Internal Medicine, Nihon University
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- ARAKAWA Yasuyuki
- The Third Department of Internal Medicine, Nihon University
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- OKANO Tadao
- Toubu Chiiki Hospital
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説明
Objective Evaluation of the usefulness of the serial daterminations of serum alpha-L-fucosidase (AFU) activity for prediction of the development of hepatocellular carcinoma (HCC) was performed. Methods and Patients Serum AFU activity was determined monthly for 42 months in 73 patients with liver cirrhosis (LC). Results HCC was diagnosed in 27 patients by means of ultrasonography during this observation period. In 23 (85%) of the 27 patients, serum AFU activity was found to exceed 700 nmole/ml/h during the LC stage. HCC developed within a few years in 23 (82%) of 28 LC patients with AFU activity exceeding 700 nmole/ml/h, in contrast, it developed in only 4 (9%) of 45 LC patients with AFU activity below 700 nmole/ml/h. AFU activity was already elevated in 23 (85%) of 27 patients at least 6 months before the detection of HCC by ultrasonography. Conclusion It is conceivable that the development of HCC can be predicted by means of serial determinations of serum AFU activity in patients with LC.<br>(Internal Medicine 38: 927-931, 1999)
収録刊行物
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- Internal Medicine
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Internal Medicine 38 (12), 927-931, 1999
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679844325632
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- NII論文ID
- 10005531067
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- NII書誌ID
- AA10827774
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- COI
- 1:STN:280:DC%2BD3c%2Fpt1Gmsg%3D%3D
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- ISSN
- 13497235
- 09182918
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- NDL書誌ID
- 4943709
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- PubMed
- 10628928
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可