Changes in Squamous Cell Carcinoma-related Antigen Levels before and after Hemodialysis in Relation to the Model of Dialyzer Employed.

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Objective Although tumor marker levels in blood become elevated after hemodialysis as a result of the amount of fluid removed, serum squamous cell carcinoma-related antigen (SCC) levels have not been always reported to increase after hemodialysis. The purpose of this report is to determine whether there is a difference between the change of serum SCC levels before and after hemodialysis according to the model of dialyzer employed.<br> Patients and Methods In ninety-four patients on hemodialysis (50 cases of diabetic nephropathy and 44 cases of glomerulonephritis), we examined serum SCC levels before and after hemodialysis.<br> Results There was no overall difference between SCC levels before and after hemodialysis (3.2±1.5 ng/ml vs 3.3±1.7 ng/ml, p=0.2381). In patients treated with a cellulosic type membrane dialyzer (n=73), SCC levels after hemodialysis were higher than those before hemodialysis (3.7±1.7 ng/ml vs 3.5±1.5 ng/ml, p=0.0495). In patients treated with a synthetic type membrane (n=21), SCC levels after hemodialysis decreased when compared to those before hemodialysis (1.9±0.7 ng/ml vs 2.2±0.8 ng/ml, p=0.0018) and in all patients, the SCC levels after hemodialysis were lower than, or equal to, those before hemodialysis.<br> Conclusion The results suggest that the decline in serum SCC levels during hemodialysis treated with synthetic type membrane of dialyzers, concealed the increased SCC levels in hemoconcentration.<br>(Internal Medicine 39: 291-295, 2000)

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  • Internal Medicine

    Internal Medicine 39 (4), 291-295, 2000

    一般社団法人 日本内科学会

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