Successful Treatment of Chronic Pulmonary Thromboembolism by Long-term Intermittent Administration of Milrinone, a Phosphodiesterase-III Inhibitor.

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  • SONODA Koichiro
    Nagasaki Memorial Hospital
  • IKEDA Satoshi
    The Second Department of Internal Medicine, Nagasaki University, School of Medicine
  • MIYAHARA Yoshiyuki
    The Second Department of Internal Medicine, Nagasaki University, School of Medicine
  • KOHNO Shigeru
    The Second Department of Internal Medicine, Nagasaki University, School of Medicine

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  • Successful Treatment of Chronic Pulmonary Thromboembolism by Long-term Intermittent Administration of Milrinone, a Phosphodiesterase-3 Inhibitor

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We report a 71-year-old man with right heart failure due to chronic pulmonary thromboembolism. Oral medications failed to control the condition but he was later successfully treated with intermittent administration of a PDE-III inhibitor for 2 years. Such therapy did not result in exacerbation of right heart failure but improvement of ANP/BNP levels to 32/104 pg/ml from a pretreatment value of 61/158 pg/ml, although no improvement was noted in pulmonary artery pressure or cardiac index. Intermittent administration of PDE-III inhibitors is a useful treatment for patients with right heart failure resistant to oral agents.<br>(Internal Medicine 41: 961-966, 2002)

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  • Internal Medicine

    Internal Medicine 41 (11), 961-966, 2002

    The Japanese Society of Internal Medicine

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