An Autopsy Case of Amyotrophic Lateral Sclerosis Accompanied by Syndrome of Inappropriate Secretion of Antidiuretic Hormone.

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  • KOYAMA Satoshi
    The First Department of Medicine (Section of Neurology), Asahikawa Medical College
  • AIZAWA Hitoshi
    The First Department of Medicine (Section of Neurology), Asahikawa Medical College
  • HAGA Tomoaki
    The First Department of Medicine (Section of Neurology), Asahikawa Medical College
  • NAKATANI-ENOMOTO Setsu
    The First Department of Medicine (Section of Neurology), Asahikawa Medical College
  • KIKUCHI Kenjiro
    The First Department of Medicine (Section of Neurology), Asahikawa Medical College

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  • Autopsy Case of Amyotrophic Lateral Sclerosis Accompanied by Syndrome of Inappropriate Secretion of Antidiuretic Hormone

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Abstract

We report an autopsy-confirmed case of amyotrophic lateral sclerosis (ALS) accompanied by syndrome of inappropriate secretion of antidiuretic hormone (SIADH). A 67-year-old man was admitted to our hospital with muscle weakness, dysarthria and dysphagia. During hospitalization, respiratory insufficiency was ingravescent, and hyponatremia, hypo-osmolarity, elevated osmotic pressure of urine, and elevated urinary sodium excretion were noted. Based on these findings we diagnosed ALS with SIADH, and treatment with infusion of concentrated NaCl was started. However, the patient died of respiratory failure on day 50. We assumed that severely restrictive ventilatory impairment was the cause of SIADH in this case.<br>(Intrenal Medicine 41: 395-397, 2002)

Journal

  • Internal Medicine

    Internal Medicine 41 (5), 395-397, 2002

    The Japanese Society of Internal Medicine

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