Antibody to Hepatitis B e Positive Hepatitis Induced by Withdrawal of Steroid Therapy for Polymyositis: Response to Interferon-Alpha and Cyclosporin A.

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  • Antibody to Hepatitis B e Positive Hepa

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Abstract

A 57-year-old woman was admitted with symmetrical proximal muscle weakness, liver dysfunction, abnormal muscle enzymes, and she was an antibody to hepatitis B e (anti-HBe) positive hepatitis B virus (HBV) carrier. Biopsy of her left quadriceps femoris showed myositis, so prednisolone was started at 40 mg/day. However, her hepatic function deteriorated and liver biopsy after 4 months showed acute hepatitis with partial submassive necrosis. Treatment with interferonalpha and cyclosporin A progressively reduced the transaminase and HBV-DNA levels. Early treatment with interferon-alpha plus cyclosporin A can control exacerbation of hepatitis B.<br>(Internal Medicine 37: 519-522, 1998)

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  • Internal Medicine

    Internal Medicine 37 (6), 519-522, 1998

    The Japanese Society of Internal Medicine

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