Cardiomyopathy with Prominent Autophagic Degeneration, Accompanied by an Elevated Plasma Brain Natriuretic Peptide Level Despite the Lack of Overt Heart Failure

DOI IR HANDLE Web Site Web Site View 1 Remaining Hide 1 Citations 23 References
  • SAIJO Mieko
    Second Department of Internal Medicine, Gifu University School of Medicine
  • TAKEMURA Genzou
    Second Department of Internal Medicine, Gifu University School of Medicine
  • KODA Masahiko
    Second Department of Internal Medicine, Gifu University School of Medicine
  • OKADA Hideshi
    Second Department of Internal Medicine, Gifu University School of Medicine
  • MIYATA Shusaku
    Second Department of Internal Medicine, Gifu University School of Medicine
  • OHNO Yasushi
    Second Department of Internal Medicine, Gifu University School of Medicine
  • KAWASAKI Masanori
    Second Department of Internal Medicine, Gifu University School of Medicine
  • TSUCHIYA Kunihiko
    Second Department of Internal Medicine, Gifu University School of Medicine
  • NISHIGAKI Kazuhiko
    Second Department of Internal Medicine, Gifu University School of Medicine
  • MINATOGUCHI Shinya
    Second Department of Internal Medicine, Gifu University School of Medicine
  • GOTO Koshi
    Second Department of Internal Medicine, Gifu University School of Medicine
  • FUJIWARA Hisayoshi
    Second Department of Internal Medicine, Gifu University School of Medicine

Search this article

Abstract

A 75-year-old man without overt heart failure showed an abnormally high level of brain natriuretic peptide (BNP) in plasma: 600 pg/ml. The left ventricular endomyocardial biopsy revealed prominent vacuolar degeneration in the myocytes, most of which were positive for PAS stain and BNP immunoreaction. Ultrastructurally, degenerative changes of myocytes were marked, such as deposits of glycogen and lipofuscin granules in the cytoplasm, but the most prominent finding was giant vacuoles containing degraded mitochondria, glycogen granules, myofibrils, and myelin-like structures (autophagosomes). This case may belong to one of the unclassified cardiomyopathies characterized by prominent autophagic vacuoles.

Journal

  • Internal Medicine

    Internal Medicine 43 (8), 700-703, 2004

    The Japanese Society of Internal Medicine

Citations (1)*help

See more

References(23)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top