Hepatic Veno-Occlusive Disease in a Case of Polymyositis Associated with Thrombotic Thrombocytopenic Purpura/hemolytic Uremic Syndrome.

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  • ISHIDA Yoh-ichi
    The Department of Internal Medicine, Toyama City Hospital
  • UTIKOSHI Manabu
    The Department of Internal Medicine, Toyama City Hospital
  • KUROSAKI Masao
    The Department of Internal Medicine, Toyama City Hospital
  • OHTA Katuroh
    The Department of Internal Medicine, Toyama City Hospital
  • CHUJO Tatsuya
    The Department of Internal Medicine, Toyama City Hospital
  • AOYAMA Shou
    The Department of Internal Medicine, Toyama City Hospital
  • OHSAWA Kenzo
    The Department of Internal Medicine, Toyama City Hospital
  • SAITO Katsuhiko
    The Department of Pathology and Laboratory Medicine, Toyama City Hospital
  • YOKOYAMA Hitoshi
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • OHTA Satoshi
    The First Department of Internal Medicine, School of Medicine, Kanazawa University

書誌事項

タイトル別名
  • Hepatic Veno-Occlusive Disease in a Cas

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抄録

A 50-year-old woman was treated with prednisolone for polymyositis. During the therapy, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) occurred. Neither plasma infusion nor plasma exchange could relieve the clinical manifestations of TTP/HUS. Moreover, massive ascites appeared and worsened her condition. She died approximately one year after the diagnosis of polymyositis. The autopsy revealed centri-lobular hepatic necrosis and nonthrombotic obliteration of hepatic small veins. The diagnosis of hepatic veno-occlusive disease (VOD) was made. It was suspected that common factors other than cytoreductive therapy had damaged the endothelium and caused TTP/HUS and VOD in a case of polymyositis.<br>(Internal Medicine 37: 694-699, 1998)

収録刊行物

  • Internal Medicine

    Internal Medicine 37 (8), 694-699, 1998

    一般社団法人 日本内科学会

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