Hepatocellular Carcinoma in a Patient with Liver Cirrhosis Associated with Negative Serum HCV Tests but Positive Liver Tissue HCV RNA

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  • ESAKI Tomoka
    Third Department of Medicine, Fukuoka University School of Medicine
  • SUZUKI Norihisa
    Third Department of Medicine, Fukuoka University School of Medicine
  • YOKOYAMA Keiji
    Third Department of Medicine, Fukuoka University School of Medicine
  • IWATA Kaoru
    Third Department of Medicine, Fukuoka University School of Medicine
  • IRIE Makoto
    Third Department of Medicine, Fukuoka University School of Medicine
  • ANAN Akira
    Third Department of Medicine, Fukuoka University School of Medicine
  • NAKANE Hidetoshi
    Third Department of Medicine, Fukuoka University School of Medicine
  • YOSHIKANE Makoto
    Third Department of Medicine, Fukuoka University School of Medicine
  • NISHIZAWA Shinya
    Third Department of Medicine, Fukuoka University School of Medicine
  • UEDA Syuichi
    Third Department of Medicine, Fukuoka University School of Medicine
  • SOHDA Tetsuro
    Third Department of Medicine, Fukuoka University School of Medicine
  • WATANABE Hiroshi
    Third Department of Medicine, Fukuoka University School of Medicine
  • SAKISAKA Shotaro
    Third Department of Medicine, Fukuoka University School of Medicine

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Description

A 70-year-old woman was admitted to our hospital because of a liver tumor. Laboratory data revealed mild liver dysfunction. Neither serum anti-HCV antibody nor HCV-RNA was detected. Computed tomography revealed a tumor lesion measuring 2 cm in diameter within the liver. Histological examination of the tumor revealed moderately differentiated hepatocellular carcinoma while the non-tumorous liver tissue demonstrated liver cirrhosis. By the RT-PCR method, HCV-RNA was detected from the non-tumorous liver tissue. We herein report a very rare case of hepatocellular carcinoma in a patient with liver cirrhosis associated with negative serum HCV findings, but positive finding for liver tissue HCV RNA.

Journal

  • Internal Medicine

    Internal Medicine 43 (4), 279-282, 2004

    The Japanese Society of Internal Medicine

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