CBFB/MYH11 Fusion Transcripts in A Case of Acute Myelogenous Leukemia (M1) with Partial Deletion of the Long Arm of Chromosome 16.
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- USUKI Kensuke
- The Division of Hematology, Kanto Teishin Hospital
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- NAKATSU Masami
- Institute of Medical Information, Kanto Teishin Hospital
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- KITAZUME Koichi
- The Division of Hematology, Kanto Teishin Hospital
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- ENDO Mitsue
- The Division of Hematology, Kanto Teishin Hospital
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- OSAWA Mayumi
- The Division of Hematology, Kanto Teishin Hospital
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- IKI Seiko
- The Division of Hematology, Kanto Teishin Hospital
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- ARAI Masanobu
- Institute of Medical Information, Kanto Teishin Hospital
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- URABE Akio
- The Division of Hematology, Kanto Teishin Hospital
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説明
Pericentric inversion of chromosome 16 [inv(16)(p13q22)] is seen in patients with acute myelomonocytic leukemia with bone marrow eosinophilia. This inversion juxtaposes the MYH11 gene on p13 and the CBFB gene on q22, resulting in the formation of a chimeric mRNA transcript. We describe a patient with acute myelogenous leukemia (M1), with del(16)(q22), who expressed the chimeric transcript. Reverse transcriptase polymerase chain reaction and the sequencing of its product showed fusion of 5'CBFB at position 495 to 3'MYH11 at position 1201. To our knowledge, this is the first report of an AML (M1) case with del(16) and CBFB/MYH11 rearrangement.<br>(Internal Medicine 35: 327-330, 1996)
収録刊行物
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- Internal Medicine
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Internal Medicine 35 (4), 327-330, 1996
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679845325952
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- NII論文ID
- 10006804580
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- NII書誌ID
- AA10827774
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- COI
- 1:STN:280:BymA3MbjtlE%3D
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- ISSN
- 13497235
- 09182918
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- PubMed
- 8739792
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
