An Autopsy Case of Wegener′s Granulomatosis with Pachymeningitis

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  • TOJO Jun
    The Department of Internal Medicine II, Fukushima Medical University, School of Medicine
  • NISHIMAKI Tomoe
    The Department of Internal Medicine II, Fukushima Medical University, School of Medicine
  • OHYANAGI Hironobu
    The Department of Internal Medicine II, Fukushima Medical University, School of Medicine
  • SAITO Ayako
    The Department of Internal Medicine II, Fukushima Medical University, School of Medicine
  • OHIRA Hiromasa
    The Department of Internal Medicine II, Fukushima Medical University, School of Medicine
  • SAKA Mitsuru
    The Department of Internal Medicine II, Fukushima Medical University, School of Medicine
  • KURODA Masahito
    The Department of Internal Medicine II, Fukushima Medical University, School of Medicine
  • ISHIKAWA Hidemasa
    The Department of Internal Medicine II, Fukushima Medical University, School of Medicine
  • KASUKAWA Reiji
    The Department of Internal Medicine II, Fukushima Medical University, School of Medicine

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タイトル別名
  • An Autopsy Case of Wegener''s Granulomatosis with Pachymeningitis
  • Autopsy Case of Wegener s Granulomatosi

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抄録

A 61-year-old woman presented with high fever, headache and left facial palsy with diplopia. Histopathological examination of the biosied specimens taken from nasal mucosa and kidney revealed a granulomatous angiitis with giant cell infiltration. Ga-DTPA-enhanced magnetic resonance imaging (MRI) revealed a thickening of dura mater in the middle cranial fossa and tentorium cerebelli. The observed left facial and occulomotor palsy was considered to be caused by pachv meningitis associated with Wegener's granulomatosis (WG). Cyclophosphamide combined with prednisolone effectively improved the symptoms. However, the patient died of acute interstitial pneumonitis, presumably caused by cyclophosphamide. The pathohistology obtained in the autopsy revealed a fibrous thickening of the dura mater in the left meningen with a segmental scarring of the arteries and a necrotizing arteritis in the kidney.<br>(Internal Medicine 37: 711-715, 1998)

収録刊行物

  • Internal Medicine

    Internal Medicine 37 (8), 711-714, 1998

    一般社団法人 日本内科学会

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