Nocturnal Polyuria with Abnormal Circadian Rhythm of Plasma Arginine Vasopressin in Post-stroke Patients
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- SAKAKIBARA Ryuji
- Department of Neurology, Chiba University Department of Neurology, Kashima Rosai Hospital, Ibaragi
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- UCHIYAMA Tomoyuki
- Department of Neurology, Chiba University
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- LIU Zhi
- Department of Neurology, Chiba University
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- YAMAMOTO Tatsuya
- Department of Neurology, Chiba University
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- ITO Takashi
- Department of Neurology, Chiba University
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- YAMANISHI Tomonori
- Department of Urology, Dokkyo Medical College, Tochigi
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- HATTORI Takamichi
- Department of Neurology, Chiba University
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Description
Objective Nocturia is a common reason for interrupted sleep in post-stroke patients. These patients often have neurogenic bladder overactivity. However, little is known about the possible contribution of nocturnal polyuria in the patients.<BR>Methods We measured the number of nocturia, the circadian plasma arginine vasopressin (AVP) level and urinary excretion in 4 patients with stroke.<BR>Results All patients had nocturnal urinary frequency (three times in one and twice in 3). All patients were revealed to have nocturnal polyuria, and the ratio of nocturnal urinary output to 24 hour volume ranged from 36% to 63%. Measurement of daily plasma AVP variation showed that all patients lost normal nocturnal rise of the plasma AVP concentration. Two patients were successfully treated with 5 μg of intranasal desmopressin once a night, a potent analogue of AVP, without hypertension particularly in the night, signs of congestive cardiac failure or any electrolyte abnormality such as hyponatremia.<BR>Conclusion Our post-stroke patients had nocturnal polyuria with abnormal circadian rhythm of plasma AVP secretion. Desmopressin reduced nocturnal waking in urination. It also ameliorated nocturnal dehydration that might trigger a stroke recurrence in the patients.
Journal
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- Internal Medicine
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Internal Medicine 44 (4), 281-284, 2005
The Japanese Society of Internal Medicine
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Details 詳細情報について
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- CRID
- 1390282679845627136
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- NII Article ID
- 10015461718
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- NII Book ID
- AA10827774
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- ISSN
- 13497235
- 09182918
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- NDL BIB ID
- 7301468
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- PubMed
- 15897635
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed