Gastric Dysmotility Associated with Accumulation of Mitochondrial A3243G Mutation in the Stomach

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  • FUJII Akihiro
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
  • YONEDA Makoto
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
  • OHTANI Masahiro
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
  • NAKAGAWA Hiroto
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
  • KUMANO Takanori
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
  • HAYASHI Koji
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
  • MURAMATSU Atsushi
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
  • TAKABATAKE Satoru
    Department of Internal Medicine, Fukui General Hospital
  • IBI Tohru
    Department of Neurology, Aichi Medical University School of Medicine
  • SAHASHI Ko
    Department of Neurology, Aichi Medical University School of Medicine
  • AZUMA Takeshi
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
  • KURIYAMA Masaru
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui

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Description

  Objective  We analyzed the accumulation of a mitochondrial A-to-G mutation at nucleotide position 3243 (A3243G) in the stomach and gastric motility in patients with gastric symptoms, post-prandial nausea/vomiting and epigastralgia.<br>  Methods  Detection and quantification of A3243G mutation in mtDNA in the gastric mucosa, oral mucosa, leukocyte, and skeletal muscle were performed. Gastric motility was evaluated by gastric myoelectrical activity on electrogastrography (EGG), and gastric emptying was evaluated by measurement of plasma paracetamol concentration before and after meals.<br>  Patients or Materials  Four patients with A3243G mutation in the leukocyte mtDNA and gastric symptoms were examined.<br>  Results  The A3243G mutation was detected at higher percentages in the gastric body (69-94% for mutation; mean, 83%) than in the angle portion (37-82%; mean, 52%), the antrum (40-84%; mean, 57%) or leukocytes (28-52%; mean, 39%), and at slightly higher percentages than in the skeletal muscles (45-87%; mean, 70%) or oral mucosae (52-86%; mean, 69%) in the four patients examined. Abnormal EGGs were observed in the three patients examined. The pre-prandial myoelectrical activities were low in these patients (49% in patient 1, 54% in patient 2, 63% in patient 3; normal >70%). The plasma concentrations of paracetamol were low (3.6 μg/ml in patient 1, 2.4 μg/ml in patient 2, <2.0 μg/ml in patient 3; normal, 7-12 μg/ml).<br>  Conclusion  Accumulation of mitochondrial A3243G mutation in the stomach is a contributory factor in gastric dysmotility and gastric symptoms in patients with the mutation in their leukocytes.

Journal

  • Internal Medicine

    Internal Medicine 43 (12), 1126-1130, 2004

    The Japanese Society of Internal Medicine

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