Pulmonary Manifestations in Cerebrotendinous Xanthomatosis.
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- KAWABATA Masaharu
- The Third Department of Internal Medicine, Kagoshima University School of Medicine
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- KURIYAMA Masaru
- The Third Department of Internal Medicine, Kagoshima University School of Medicine
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- MORI Shinitirou
- The Third Department of Internal Medicine, Kagoshima University School of Medicine
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- SAKASHITA Izumi
- The Third Department of Internal Medicine, Kagoshima University School of Medicine
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- OSAME Mitsuhiro
- The Third Department of Internal Medicine, Kagoshima University School of Medicine
Bibliographic Information
- Other Title
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- Pulmonary Manifestations in Cerebrotend
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Abstract
We investigated five cases with cerebrotendinous xanthomatosis (CTX) with particular reference to biochemical and pathological pulmonary disorders. To date, few reports discuss the pathophysiology of pulmonary disorders of CTX patients. This study is the first investigation of such pulmonary disorders. All 5 patients had no pulmonary symptoms and no disturbances on radiological studies and pulmonary function tests. However, in bronchoalveolar lavage (BAL) fluids, many cells with cruciform reflexes, which is characteristic of intracellular sterol accumulation, were found under phase contrast microscopy. Biochemically, cholestanol was found to be increased in the BAL fluid as well as in serum. Pathological findings of transbronchial lung biopsy (TBLB) samples disclosed foamy macrophages and small granulomas in alveolar septa. In conclusion, the lung was apparently involved in CTX, and the lesions were characterized with the accumulation of foamy and giant cells with a high concentration of cholestanol, which likely results in the formation of foreign body granulomas.<br>(Internal Medicine 37: 922-926, 1998)
Journal
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- Internal Medicine
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Internal Medicine 37 (11), 922-926, 1998
The Japanese Society of Internal Medicine
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Keywords
Details 詳細情報について
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- CRID
- 1390282679845825408
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- NII Article ID
- 10007605716
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- NII Book ID
- AA10827774
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- COI
- 1:STN:280:DyaK1M%2FosVaqtQ%3D%3D
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- ISSN
- 13497235
- 09182918
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- NDL BIB ID
- 4614188
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- PubMed
- 9868952
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed