Mechanism of Increased Serum Cytokeratin 19 Fragment Levels in Patients with Diabetic Nephropathy as a Model of Chronic Renal Failure.
-
- KASHIWABARA Kosuke
- The Fifth Department of Internal Medicine, Tokyo Medical College
-
- KISHI Koji
- The Fifth Department of Internal Medicine, Tokyo Medical College
-
- NAKAMURA Hiroyuki
- The Fifth Department of Internal Medicine, Tokyo Medical College
-
- YAGYU Hisanaga
- The Fifth Department of Internal Medicine, Tokyo Medical College
-
- KOBAYASHI Katsuyuki
- The Fifth Department of Internal Medicine, Tokyo Medical College
-
- WATANABE Osamu
- The Fifth Department of Internal Medicine, Tokyo Medical College
-
- MATSUOKA Takeshi
- The Fifth Department of Internal Medicine, Tokyo Medical College
書誌事項
- タイトル別名
-
- Mechanism of Increased Serum Cytokerati
この論文をさがす
説明
We examined serum and urinary cytokeratin 19 fragment (CYFRA 21-1) levels in patients with diabetic nephropathy as a model of chronic renal failure, to investigate the mechanism of increased serum CYFRA 21-1 levels in chronic renal failure. Serum and urinary CYFRA 21-1 levels in non-insulin-dependent diabetes mellitus (NIDDM) patients with abnormal urinary immunoglobulin G (IgG) levels (>1.1 mg/g • Cr, n=126) were higher than those with normal urinary IgG levels. In NIDDM patients with normal urinary IgG levels (n=81); the urinary albumin or transferrin levels were not related to serum or urinary CYFRA 21-1 levels. We speculate that the increased serum CYFRA 21-1 levels contribute to metabolic abnormality in the kidney itself rather than the decreased urinary excretion per se, and that increased urinary CYFRA 21-1 levels are found in advanced cases of diabetic nephropathy with destruction of the size barrier.<br>(Internal Medicine 37: 917-921, 1998)
収録刊行物
-
- Internal Medicine
-
Internal Medicine 37 (11), 917-921, 1998
一般社団法人 日本内科学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679845858304
-
- NII論文ID
- 10007605698
-
- NII書誌ID
- AA10827774
-
- COI
- 1:STN:280:DyaK1M%2FosVaqtA%3D%3D
-
- ISSN
- 13497235
- 09182918
-
- NDL書誌ID
- 4614187
-
- PubMed
- 9868951
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可