Liver Transplantation-associated Hypercalcemia Followed by Acute Renal Dysfunction
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- SHIRASAWA Yuichi
- Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences
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- NOMURA Tomoyuki
- Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences
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- YOSHIDA Atsuhiro
- Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences
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- HASHIMOTO Takashi
- Division of Pediatric and Transplant Surgery, Nagoya City University Graduate School of Medical Sciences
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- KIMURA Genjiro
- Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences
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- ITO Makoto
- Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences
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Abstract
A 34-year-old woman with liver insufficiency due to glycogen storage disease III underwent a living spousal liver transplantation. Soon after the successful operation, moderate hypercalcemia along with hyperbilirubinemia emerged without clarified reasons. The hypercalcemia persisted for over a month despite calcitonin treatment and the serum calcium level surged to 13.2mg/dl with albumin correction. Renal dysfunction was indicated by an acute increase in serum creatinine (∼0.8 to ∼2.8mg/ml), which was assumed to be hypercalcemia-induced and was effectively treated with bisphosphonate, pamidronate (30 mg, i.v.). Recent topics related to transplantation-associated hypercalcemia are discussed.
Journal
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- Internal Medicine
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Internal Medicine 43 (9), 802-806, 2004
The Japanese Society of Internal Medicine