CD56+CD7+Stem Cell Leukemia/Lymphoma with D2-Jδ1 Rearrangement

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  • YOSHIDA Tetsuya
    The First Department of Internal Medicine, Fukuoka University School of Medicine
  • KIMURA Nobuhiro
    The First Department of Internal Medicine, Fukuoka University School of Medicine
  • SAWADA Hitoshi
    The Division of Internal Medicine, Kokura Memorial Hospital
  • SUEMATSU Eiichi
    The Division of Internal Medicine, Fukuoka Teishin Hospital
  • NAGANO Mitsuyuki
    The First Department of Internal Medicine, Fukuoka University School of Medicine
  • AKIYOSHI Tomi
    The First Department of Internal Medicine, Fukuoka University School of Medicine
  • MOTOMURA Seiji
    The Division of Internal Medicine, Fukuoka Teishin Hospital
  • KIKUCHI Masahiro
    The First Department of Pathology, Fukuoka University School of Medicine
  • NISHIMURA Junji
    The Third Department of Internal Medicine, Kyushu University
  • TAMURA Kazuo
    The First Department of Internal Medicine, Fukuoka University School of Medicine

書誌事項

タイトル別名
  • CD56+ CD7+ Stem Cell Leukemia/Lymphoma with D2-J.DELTA.1 Rearrangement.
  • CD56 CD7 Stem Cell Leukemia Lymphoma with D2-J デルタ 1 Rearrangement

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Object We describe the characteristics of three patients with CD56+CD7+ stem cell leukemia/lymphoma. Methods These blasts were analyzed for morphologic, karyotypic, immunophenotypic, and immunogenotypic features using Southern blot and polymerase chain reaction analysis. Materials Peripheral blood, bone marrow aspirates, or biopsied mediastinal tumor specimens of three CD56+CD7+ stem cell leukemia/lymphoma patients were investigated. Results The bone marrow of all patients showed myeloperoxidase (MPO) negative blast cells with basophilic cytoplasm and distinct nucleoli with no azurophilic granules. The blasts of two patients were classified as acute lymphoblastic leukemia (L2). The liver, spleen, and lymph nodes were unaffected in all patients. AH had an aggressive clinical course. The blasts were strongly positive for both CD7 and CD56 but negative for other T-lineage associated antigens, including CD1, CD2, surface membrane CD3, cytoplasmic CD3c (2/2), CD4, CDS and CDS. The additional antigens were recognized as follows: CD19 (1/3 cases) as a B lineage, CD33 (1/3) as a myeloid marker, CD34 (2/3) as a stem cell, CD38 (1/1) and HLA-DR (2/3). When the patients relapsed, the phenotypes changed to blasts positive for CDS, CD10 and CD13 in patient 1, CDS in patient 2, and CD33 in patient 3. MPO, however, remained negative. Cytogenetic analysis showed no common abnormal karyotype. All had a common D2-Jδ1 induced by T-cell specific enhancer. Rearrangement of TCR β and γ genes occurred in patient 2, and IgH and TCR β underwent rearrangement in patient 3. Conclusion Although a more comprehensive case analysis is necessary, these data suggest the possibility that the blasts of the present cases come from a common lymphoid precursor (T, NK, and B cell) or from a NKT precursor as the fourth lymphoid lineage.<br>(Internal Medicine 38: 547-555, 1999)

収録刊行物

  • Internal Medicine

    Internal Medicine 38 (7), 547-555, 1999

    一般社団法人 日本内科学会

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