Chemokine/Receptor Dynamics in the Regulation of Hematopoiesis.

DOI Web Site Web Site PubMed 74 References Open Access
  • MAEKAWA Taira
    Department of Transfusion Medicine and Cell Therapy, The Institute of Medical Science, The University of Tokyo
  • ISHII Takefumi
    Department of Transfusion Medicine and Cell Therapy, The Institute of Medical Science, The University of Tokyo

Search this article

Description

Recently, a close association between hematopoiesis and chemokines and their receptors has been demonstrated. Much attention has been focused on the regulation of hematopoiesis by chemokines, because of the possibility of direct consequence for clinical practice in cell therapies such as hematopoietic stem cell transplantation. This report reviews the physiological roles of chemokines and their receptors in the context of hematopoietic cell regulation, with particular focus on the involvement of stromal cell derived factor (SDF)-l/pre-B cell growth stimulating factor (PBSF) and its receptor CXCR4. The proliferation, differentiation, migration, and engraftment of hematopoietic stem cells are discussed, and thereby raise a number of unresolved problems and points-to-consider.<br>(Internal Medicine 39: 90-100, 2000)

Journal

  • Internal Medicine

    Internal Medicine 39 (2), 90-100, 2000

    The Japanese Society of Internal Medicine

References(74)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top