Malignant Meningitis Secondary to Lung Adenocarcinoma: An Unusual Relapse

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  • Ano Satoshi
    Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba
  • Satoh Hiroaki
    Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba
  • Nakazawa Kensuke
    Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba
  • Ohtsuka Morio
    Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba
  • Anami Youichi
    Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba
  • Noguchi Masayuki
    Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba
  • Hizawa Nobuyuki
    Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba

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Abstract

We describe a 64-year-old man with locally advanced lung adenocarcinoma who had meningeal relapse soon after the completion of intensive chemo-radiotherapy. Diagnosis of the malignant meningitis was established by cytological examination of the cerebrospinal fluid, which showed malignant cells consistent with adenocarcinoma from the primary site. Although very rare, it is possible that successful chemo-radiotherapy for locally advanced lung cancer could not prevent malignant meningitis as observed in our patient. Physicians should consider performance of brain MRI or contrast CT of the brain and a lumbar puncture to exclude the diagnosis of malignant meningitis, an uncommon but devastating complication of malignancy.<br>

Journal

  • Internal Medicine

    Internal Medicine 46 (20), 1749-1752, 2007

    The Japanese Society of Internal Medicine

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