Bosentan Ameliorated Exercise-Induced Pulmonary Arterial Hypertension Complicated with Systemic Sclerosis
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- Yagi Shusuke
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Akaike Masashi
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Iwase Takashi
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Kusunose Kenya
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Niki Toshiyuki
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Yamaguchi Koji
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Koshiba Kunihiko
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Yoshida Sumiko
- Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences
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- Sumitomo-Ueda Yuka
- Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences
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- Aihara Ken-ichi
- Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences
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- Hirata Yoichiro
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Dagvasumberel Munkhbaatar
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Taketani Yoshio
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Tomita Noriko
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Yamada Hirotsugu
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Soeki Takeshi
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Wakatsuki Tetsuzo
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Matsumoto Toshio
- Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences
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- Sata Masataka
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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抄録
Pulmonary arterial hypertension (PAH) is a frequent complication in patients with systemic sclerosis. Bosentan is used in patients with symptomatic PAH; however, it has not been established whether or not bosentan ameliorates the progression of PAH in patients with no PAH-related symptoms.<br> We present a case of systemic sclerosis with no PAH-related symptoms in which bosentan ameliorated exercise-induced PAH evaluated by 6-minute walk stress echocardiography, brachial flow-mediated dilation, and skin temperature of hands and feet. The results suggest that administration of bosentan in patients with early-stage PAH ameliorates pulmonary arterial vasodilatation through improvement of endothelial function.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 49 (21), 2309-2312, 2010
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679847104768
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- NII論文ID
- 130000413347
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- ISSN
- 13497235
- 09182918
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可