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Bosentan Ameliorated Exercise-Induced Pulmonary Arterial Hypertension Complicated with Systemic Sclerosis
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- Yagi Shusuke
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Akaike Masashi
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Iwase Takashi
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Kusunose Kenya
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Niki Toshiyuki
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Yamaguchi Koji
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Koshiba Kunihiko
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Yoshida Sumiko
- Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences
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- Sumitomo-Ueda Yuka
- Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences
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- Aihara Ken-ichi
- Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences
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- Hirata Yoichiro
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Dagvasumberel Munkhbaatar
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Taketani Yoshio
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Tomita Noriko
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Yamada Hirotsugu
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Soeki Takeshi
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Wakatsuki Tetsuzo
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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- Matsumoto Toshio
- Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences
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- Sata Masataka
- Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
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Description
Pulmonary arterial hypertension (PAH) is a frequent complication in patients with systemic sclerosis. Bosentan is used in patients with symptomatic PAH; however, it has not been established whether or not bosentan ameliorates the progression of PAH in patients with no PAH-related symptoms.<br> We present a case of systemic sclerosis with no PAH-related symptoms in which bosentan ameliorated exercise-induced PAH evaluated by 6-minute walk stress echocardiography, brachial flow-mediated dilation, and skin temperature of hands and feet. The results suggest that administration of bosentan in patients with early-stage PAH ameliorates pulmonary arterial vasodilatation through improvement of endothelial function.<br>
Journal
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- Internal Medicine
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Internal Medicine 49 (21), 2309-2312, 2010
The Japanese Society of Internal Medicine