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Rescue Therapy with Tacrolimus for a Patient with Severe Ulcerative Colitis Refractory to Combination Leukocytapheresis and High-Dose Corticosteroid Therapy
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- Nakase Hiroshi
- Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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- Mikami Sakae
- Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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- Matsuura Minoru
- Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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- Ueno Satoru
- Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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- Uza Norimitsu
- Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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- Inoue Satoko
- Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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- Kitamura Hiroshi
- Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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- Kasahara Katsuhiro
- Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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- Yoshino Takuya
- Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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- Takeda Yasuhiro
- Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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- Chiba Tsutomu
- Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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Description
A19-year-old man complaining of severe diarrhea and hematochezia was admitted to our hospital. Endoscopic findings and laboratory data revealed that he had ulcerative colitis (UC). Despite combination therapy with high-dose corticosteroids and intensive granulocytapheresis, his condition did not improve. Therefore, we initiated tacrolimus therapy. Intravenous administration of tacrolimus with a trough level of 10 to 15 ng/ml relieved his abdominal symptoms within 1 week. The patient experienced no UC relapse 1 year after treatment with oral tacrolimus. Tacrolimus is a promising therapy for patients with UC refractory to the combination of high-dose corticosteroids and leukocytapheresis.<br>
Journal
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- Internal Medicine
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Internal Medicine 46 (11), 717-720, 2007
The Japanese Society of Internal Medicine