Differential Diagnosis Between Intracranial Dissemination of Spinal Cord Astrocytoma and Paraneoplastic Limbic Encephalitis

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  • Seki Morinobu
    Department of Neurology, School of Medicine, Keio University, Japan
  • Suzuki Shigeaki
    Department of Neurology, School of Medicine, Keio University, Japan
  • Ishii Ken
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Japan
  • Izawa Yoshikane
    Department of Neurology, School of Medicine, Keio University, Japan
  • Takahashi Shinichi
    Department of Neurology, School of Medicine, Keio University, Japan
  • Toyama Yoshiaki
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Japan
  • Nakamura Masaya
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Japan
  • Suzuki Norihiro
    Department of Neurology, School of Medicine, Keio University, Japan

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Description

We describe the clinical features of limbic encephalitis that developed after palliative spinal cordotomy in 2 patients with malignant thoracic astrocytoma. Both patients showed short-term memory loss, hallucinations of smells and psychiatric symptoms. Brain MRI on T2-weighted and fluid-attenuated inversion recovery sequences revealed high intensity lesions in bilateral temporal lobe areas. We considered that both patients had paraneoplastic limbic encephalitis associated with astrocytoma because of various clinical and radiological features. But the possibility of intracranial dissemination of astrocytoma could not be fully excluded. The differential diagnosis between intracranial dissemination of spinal cord astrocytoma and paraneoplastic limbic encephalitis may be sometimes difficult.<br>

Journal

  • Internal Medicine

    Internal Medicine 51 (3), 321-324, 2012

    The Japanese Society of Internal Medicine

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