Cerebral Sinus Thrombosis and Heparin-induced Thrombocytopenia in a Patient with Paroxysmal Nocturnal Hemoglobinuria

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  • Ishihara-Kawase Kayoko
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences
  • Ohtsuki Toshiho
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences
  • Sugihara Sayaka
    Department of Hematology and Oncology, Division of Clinical and Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University Graduate School of Biomedical Sciences
  • Tanaka Hitomi
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences
  • Nakamura Takeshi
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences
  • Kimura Akiro
    Department of Hematology and Oncology, Division of Clinical and Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University Graduate School of Biomedical Sciences
  • Matsumoto Masayasu
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences

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Description

Paroxysmal nocturnal hemoglobinuria is a rare acquired disorder of clonal hematopoietic stem cells and it is characterized as a hypercoagulable disorder. We report a 36-year-old woman with the rare triad of paroxysmal nocturnal hemoglobinuria, cerebral sinus thrombosis triggered by infection, and rapid-onset heparin-induced thrombocytopenia after resensitization of heparin. This case raises caution for heparin-induced thrombocytopenia in paroxysmal nocturnal hemoglobinuria.<br>

Journal

  • Internal Medicine

    Internal Medicine 49 (10), 941-943, 2010

    The Japanese Society of Internal Medicine

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