Effects of Nasal Continuous Positive Airway Pressure on the Glomerular Filtration Rate in Patients with Obstructive Sleep Apnea Syndrome

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  • Ohnuki Tomohide
    Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine, Japan
  • Takahashi Wakoh
    Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine, Japan
  • Ohnuki Youichi
    Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine, Japan
  • Kawada Shiaki
    HIMEDIC Imaging Center at Lake Yamanaka, Japan
  • Takizawa Shunya
    Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine, Japan

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  • Significance of the Presence of Metabolic Syndrome in Patients with Asymptomatic Arteriosclerosis Affecting the Aorta and the Cerebral, Extra-cranial Carotid and Coronary Arteries

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Objective The presence of metabolic syndrome (MetS) is strongly associated with stroke and cardiovascular diseases. However, the relationship between MetS and the localization of atherosclerosis at various sites remains uncertain. In this study, in order to reveal the relevance of MetS to atherosclerosis at several sites, we investigated the relationships among vascular risk factors, asymptomatic cerebral infarction and atherosclerosis in the aorta and carotid and coronary arteries in adults without overtly symptomatic cerebrovascular or cardiovascular disease.<br> Methods The subjects in this study included 2,759 Japanese participants (1,845 men and 914 women, mean age: 52 years) with no history of stroke or cardiovascular events. The diagnosis of MetS was made based on modifications to criteria obtained from the National Cholesterol Education Program Adult Treatment Panel. In all subjects, the presence of cerebral infarction in the extra-cranial carotid, coronary and aortic arteries was investigated using MRI, B-mode ultrasonography and CT.<br> Results Of the 2,759 subjects, 796 (28.9%) fulfilled the criteria for MetS. The presence of MetS increased the odds ratio (OR) to 1.89 (95% confidence interval (CI): 1.35-2.65, p-value <0.0001) for asymptomatic cerebral infarction, 1.70 (95% CI: 1.37-2.10, p-value <0.0001) for carotid arteriosclerosis, 2.07 (95% CI: 1.62-2.27, p-value <0.0001) for coronary calcification and 1.67 (95% CI: 1.33-2.09, p-value<0.0001) for aortic calcification.<br> Conclusion The presence of MetS was found to be significantly correlated with arteriosclerosis in all regions, including the cerebral small-vessels, extra-cranial carotid arteries, coronary arteries and abdominal aorta. MetS might be a predictor for small and large vessel disease throughout the body.<br>

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  • Internal Medicine

    Internal Medicine 52 (5), 523-527, 2013

    一般社団法人 日本内科学会

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