Successful Treatment of Recurrent Candidemia due to Candidal Thrombophlebitis Associated with a Central Venous Catheter Using a Combination of Fosfluconazole and Micafungin
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- Hagiya Hideharu
- Emergency Unit and Critical Care Center, Tsuyama Central Hospital, Japan
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- Kajioka Hiroki
- Department of Surgery, Tsuyama Central Hospital, Japan
書誌事項
- 公開日
- 2013
- 資源種別
- journal article
- DOI
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- 10.2169/internalmedicine.52.0584
- 公開者
- 一般社団法人 日本内科学会
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説明
We herein report the case of an 85-year-old woman presenting with right internal jugular vein candidal thrombophlebitis associated with central venous catheters (CTCVC). The infecting agent was Candida albicans, which caused recurrent candidemia five times in total. Micafungin (MCFG) alone was ineffective; however, the combination of MCFG with fosfluconazole (F-FLCZ) successfully treated the patient without a need for any anticoagulant or surgical therapies. To the extent of our knowledge, this is the first report of CTCVC being successfully treated with a combination of F-FLCZ and MCFG. These new antifungal agents have better efficacy, tolerability and bioavailability; therefore, they can be useful alternatives to classical combination therapies such as amphotericin-B and 5-fluorocytosine.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 52 (18), 2139-2143, 2013
一般社団法人 日本内科学会