Multiple Unrelated Malignancies Following Renal Transplantation: An Evaluation of Four Cases

  • Tatar Erhan
    Division of Nephrology, Ege University School of Medicine, Turkey
  • Sarsik Banu
    Division of Pathology, Ege University School of Medicine, Turkey
  • Gungor Ozkan
    Division of Nephrology, Ege University School of Medicine, Turkey
  • Yaman Banu
    Division of Pathology, Ege University School of Medicine, Turkey
  • Ozsan Nazan
    Division of Pathology, Ege University School of Medicine, Turkey
  • Cagirgan Seckin
    Division of Hematology, Ege University School of Medicine, Turkey
  • Sezis Demirci Meltem
    Division of Nephrology, Ege University School of Medicine, Turkey
  • Ozgur Sezer Taylan
    Division of General Surgery, Ege University School of Medicine, Turkey
  • Hoscoskun Cuneyt
    Division of General Surgery, Ege University School of Medicine, Turkey
  • Toz Huseyin
    Division of Nephrology, Ege University School of Medicine, Turkey

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Description

The risk of de novo malignancy is significantly higher in patients who have undergone organ transplantation than in the general population. Long-term immunosuppressive treatment, in addition to age, genetic predisposition and infectious agents, plays a major role in the development of malignancy. Although skin and hemopoietic system cancers are common, atypical presentations of malignancies may occasionally be seen during long-term follow-up in patients with functioning allografts. In this report, four cases, each with more than one different primary malignancy (one patient with three malignancies and three patients with two malignancies), are presented.<br>

Journal

  • Internal Medicine

    Internal Medicine 52 (6), 673-677, 2013

    The Japanese Society of Internal Medicine

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