Two Cases of Nonsecretory Multiple Myeloma Presenting as Primary Plasma Cell Leukemia
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- Takahashi Tohru
- Department of Hematology, Tenshi Hospital, Japan
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- Kanno Shin-ichi
- Department of Gastroenterology, Tenshi Hospital, Japan
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- Itoh Hideto
- Department of Gastroenterology, Tenshi Hospital, Japan
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- Yoshimoto Mitsuru
- Department of Gastroenterology, Tenshi Hospital, Japan
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- Tsujisaki Masayuki
- Department of Gastroenterology, Tenshi Hospital, Japan
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- Fujino Michihiro
- Department of Respiratory Medicine, Tenshi Hospital, Japan
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説明
Plasma cell leukemia (PCL) is a rare variant of multiple myeloma (MM) with a poor prognosis. Nonsecretory myeloma is also a rare form of MM characterized by the absence of detectable M-protein in the serum and urine. This report describes two cases of nonsecretory PCL. The first patient was an 85-year-old man in whom the lack of monoclonal immunoglobulins made it difficult to make a diagnosis because the malignant cells showed an atypical morphology. He died of rapid disease progression before starting chemotherapy. The second patient was a 78-year-old woman whose tumor cells displayed a typical plasma cell morphology. She was successfully treated with bortezomib-containing chemotherapy.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 53 (18), 2121-2125, 2014
一般社団法人 日本内科学会
