Benign Premature Ventricular Complexes from the Right Ventricular Outflow Tract Triggered Polymorphic Ventricular Tachycardia in a Latent Type 2 LQTS Patient
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- Sato Akinori
- Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
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- Chinushi Masaomi
- School of Health Sciences, Niigata University, Japan
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- Sonoda Keiko
- Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
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- Abe Akira
- Department of Cardiology, Niigata Minami Hospital, Japan
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- Izumi Daisuke
- Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
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- Furushima Hiroshi
- Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
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Abstract
A 57-year-old woman showed frequent premature ventricular complexes (PVCs) originating from the right ventricular outflow tract (RVOT), and some of the PVCs triggered polymorphic ventricular tachycardia (PVT). Structural heart diseases were ruled out by conventional cardiac examinations. Radiofrequency catheter ablation was successful in eliminating the PVCs and subsequent PVT. However, epinephrine infusion unmasked her prolonged QT interval, and a genetic analysis revealed a KCNH2 mutation (R694H) as the cause of latent type-2 long QT syndrome (LQTS). This case suggests that latent LQTS may work as an arrhythmogenic substrate of PVT triggered by a benign form of RVOT-PVCs in patients with a structurally normal heart.<br>
Journal
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- Internal Medicine
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Internal Medicine 51 (23), 3261-3265, 2012
The Japanese Society of Internal Medicine