Chronic Graft-versus-host Disease Presenting with Multiple Punctate Intracranial Lesions on Contrast-enhanced Magnetic Resonance Imaging

DOI 機関リポジトリ 機関リポジトリ (HANDLE) Web Site PubMed 被引用文献2件 参考文献22件 オープンアクセス
  • Terada Makoto
    Department of Neurology, Faculty of Medicine, University of Tsukuba, Japan
  • Nakamagoe Kiyotaka
    Department of Neurology, Faculty of Medicine, University of Tsukuba, Japan
  • Obara Naoshi
    Department of Hematology, Faculty of Medicine, University of Tsukuba, Japan
  • Ogawa Shinichi
    Department of Hematology, Faculty of Medicine, University of Tsukuba, Japan
  • Sakamoto Noriaki
    Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Japan
  • Sato Taiki
    Department of Diagnostic Pathology, Faculty of Medicine, University of Tsukuba, Japan
  • Nohara Seitaro
    Department of Neurology, Faculty of Medicine, University of Tsukuba, Japan
  • Chiba Shigeru
    Department of Hematology, Faculty of Medicine, University of Tsukuba, Japan
  • Tamaoka Akira
    Department of Neurology, Faculty of Medicine, University of Tsukuba, Japan

この論文をさがす

説明

<p>Central nervous system graft-versus-host disease can present quite a diagnostic challenge. We herein present a case of histologically-confirmed chronic graft versus host disease (GVHD) involving the central nervous system that occurred at 19 months after peripheral blood stem cell transplantation. Cranial magnetic resonance imaging showed areas of confluent hyperintensity in the deep/subcortical white matter with multiple punctate and curvilinear gadolinium enhancements, suggesting the disruption of the blood-brain barrier. A brain biopsy revealed perivascular CD3-positive T cell infiltration around the small vessels. We propose that the detection of punctate-enhanced lesions by magnetic resonance imaging may be a useful finding that facilitates the early diagnosis of chronic GVHD involving the central nervous system. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 56 (3), 363-368, 2017

    一般社団法人 日本内科学会

被引用文献 (2)*注記

もっと見る

参考文献 (22)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ