Effectiveness of Plasmapheresis in a Patient with Anti-glomerular Basement Membrane Antibody Glomerulonephritis with Advanced Kidney Dysfunction
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- Usui Toshiaki
- Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Kai Hirayasu
- Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Noguchi Kazuyuki
- Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Morito Naoki
- Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Usui Joichi
- Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Saito Chie
- Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Uesugi Noriko
- Department of Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, Japan
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- Nagata Michio
- Department of Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, Japan
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- Yamagata Kunihiro
- Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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Abstract
<p>Patients with anti-glomerular basement membrane antibody glomerulonephritis (anti-GBM GN) have severe kidney dysfunction, leading to end-stage renal disease. The effect of plasmapheresis and immunosuppressive treatment in patients with severe glomerular changes is controversial. A 62-year-old man was admitted with rapidly progressive glomerulonephritis and diagnosed with anti-GBM GN. He required hemodialysis. All glomeruli in the kidney biopsy specimen had cellular crescents without fibrotic changes, suggesting reversible damage. He was treated with plasmapheresis until the anti-glomerular basement membrane antibodies disappeared. His kidney function recovered, and dialysis was able to be discontinued. Frequent plasmapheresis in patients with dialysis-dependent anti-GBM GN may improve the kidney prognosis. </p>
Journal
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- Internal Medicine
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Internal Medicine 56 (18), 2475-2479, 2017
The Japanese Society of Internal Medicine
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Details
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- CRID
- 1390282679851694976
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- NII Article ID
- 130006078530
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- NII Book ID
- AA10827774
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- ISSN
- 13497235
- 09182918
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- HANDLE
- 2241/00148571
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- PubMed
- 28824070
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed