The Effects of Allopurinol on the Carotid Intima-media Thickness in Patients with Type 2 Diabetes and Asymptomatic Hyperuricemia: A Three-year Randomized Parallel-controlled Study
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- Liu Peng
- Department of Endocrinology, The Affiliated Hospital of Qingdao University, China Department of Endocrinology, Laiwu Hospital Affiliated with Taishan Medical College, China
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- Wang Huayi
- Laiwu Municipal Center for Disease Control and Prevention, China
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- Zhang Fengmei
- Department of Endocrinology, Laiwu Hospital Affiliated with Taishan Medical College, China
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- Chen Yingying
- Department of Clinical Laboratory, Laiwu Hospital Affiliated with Taishan Medical College, China
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- Wang Debao
- Department of Endocrinology, Laiwu Hospital Affiliated with Taishan Medical College, China
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- Wang Yangang
- Department of Endocrinology, The Affiliated Hospital of Qingdao University, China
書誌事項
- 公開日
- 2015
- 資源種別
- journal article
- DOI
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- 10.2169/internalmedicine.54.4310
- 公開者
- 一般社団法人 日本内科学会
この論文をさがす
説明
Objective The aim of this study was to investigate the long-term effective control of serum uric acid by allopurinol on the carotid intima-media thickness (IMT) in patients with type 2 diabetes (T2DM) and asymptomatic hyperuricemia (HUA).<br> Methods This was a randomized open parallel-controlled study. In this study, 176 patients with T2DM and asymptomatic HUA were randomly allocated to the conventional or allopurinol treatment groups on the basis of a computer-generated random number table. Changes in the carotid IMT, biochemical indexes, high sensitive C-reactive protein (hs-CRP) and the incidence of hypertension in patients before and after three years of treatment were examined and compared between the groups.<br> Results There were no statistically significant differences in the baseline characteristics of the study participants between the two treatment groups (p>0.05 for all). Nevertheless, the serum uric acid, triglyceride, and hs-CRP levels and the homeostasis assessment for insulin resistance (HOMA-IR), systolic blood pressure, diastolic blood pressure and the carotid IMT in the allopurinol group were significantly lower than those in the conventional group after three years of treatment (p<0.01 for all). The intention-to-treat analysis indicated that the incidence of new-onset hypertension in the allopurinol group showed a declining trend compared to that in the conventional treatment group (6.8% vs. 13.6%, p>0.05).<br> Conclusion The long-term effective control of serum uric acid by allopurinol may improve insulin resistance, decrease the serum levels of hs-CRP, reduce the carotid IMT, and may delay the development of atherosclerosis in patients with T2DM and asymptomatic HUA.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 54 (17), 2129-2137, 2015
一般社団法人 日本内科学会