An Impaired Awareness of Hypoglycemia Improved After Vitamin B<sub>12</sub> Treatment in a Type 1 Diabetic Patient

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  • Fujita Shingo
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
  • Kozawa Junji
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
  • Ishibashi Chisaki
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
  • Kimura Takekazu
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan Department of Diabetes Care Medicine, Graduate School of Medicine, Osaka University, Japan
  • Kitamura Tetsuhiro
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
  • Fukui Kenji
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan Department of Community Medicine, Graduate School of Medicine, Osaka University, Japan
  • Yasuda Tetsuyuki
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
  • Iwahashi Hiromi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan Department of Diabetes Care Medicine, Graduate School of Medicine, Osaka University, Japan
  • Imagawa Akihisa
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
  • Shimomura Iichiro
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan

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Description

<p>An impaired awareness of hypoglycemia is a serious problem in diabetic patients, which can lead to life-threatening severe hypoglycemia. Recurrent hypoglycemia attenuates the function of the central, mainly hypothalamic, nervous system and it causes an impaired awareness of hypoglycemia. Vitamin B12 deficiency is also associated with the dysfunction of central nervous system. We report a 72-year-old type 1 diabetic patient with vitamin B12 deficiency whose impaired awareness of hypoglycemia improved after 4 weeks of vitamin B12 administration with an increased counter-hormone secretion in response to hypoglycemia. We should recognize vitamin B12 deficiency as one of the causes of an impaired awareness of hypoglycemia in diabetic patients. </p>

Journal

  • Internal Medicine

    Internal Medicine 56 (11), 1383-1385, 2017

    The Japanese Society of Internal Medicine

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