Risk Factors for <i>Helicobacter pylori</i> Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers
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- Tanaka Yuichiro
- Departments of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, Japan
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- Sakata Yasuhisa
- Departments of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, Japan
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- Hara Megumi
- Preventive Medicine, Saga Medical School, Japan
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- Kawakubo Hiroharu
- Departments of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, Japan
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- Tsuruoka Nanae
- Departments of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, Japan
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- Yamamoto Koji
- Departments of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, Japan
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- Itoh Yoichiro
- Departments of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, Japan
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- Hidaka Hidenori
- Departments of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, Japan
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- Shimoda Ryo
- Departments of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, Japan
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- Iwakiri Ryuichi
- Departments of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, Japan
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- Fujimoto Kazuma
- Departments of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, Japan
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説明
<p>Objective The aim of this study was to determine the prevalence and risk factors of reflux esophagitis and Helicobacter pylori (H.pylori) infection and their interrelationship in healthy young Japanese volunteers. </p><p>Methods Between 2010 and 2016, 550 fifth-year medical students at Saga Medical School, aged 22 to 30 years, underwent upper gastrointestinal endoscopy and completed a questionnaire (frequency scale for symptoms of gastroesophageal reflux disease). H. pylori infection was determined by detecting urinary immunoglobulin G antibodies. </p><p>Results H. pylori antibodies were detected in 45 of the 550 subjects (8.2%). Endoscopic reflux esophagitis was detected in 38 out of 550 (6.9%): grade A in 37 subjects (97.3%) and grade B in 1. Most subjects with reflux esophagitis were H. pylori-negative (35/37). Nodular gastritis was observed in 33.3% (15/45) of H. pylori-positive subjects. The risk factors for H. pylori infection were drinking well water in childhood, nodular gastritis, and duodenal ulcer scars. The risk factors for endoscopic reflux esophagitis were male gender and obesity (body mass index ≥25). </p><p>Conclusion This study describes the risk factors for H. pylori infection and reflux esophagitis in healthy young Japanese subjects. The prevalence of reflux esophagitis was relatively high, and the infection rate of H. pylori was low compared with the aged Japanese population. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 56 (22), 2979-2983, 2017
一般社団法人 日本内科学会
