Skin Necrosis Due to the Extravasation of Irritant Anticancer Agents
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- Okuda Hiroto
- Division of Dermatology, Saiseikai Izuo Hospital, Japan School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Japan
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- Masatsugu Asako
- Division of Dermatology, Saiseikai Izuo Hospital, Japan
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- Sijimaya Takako
- Division of Dermatology, Saiseikai Izuo Hospital, Japan
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- Arai Rie
- Division of Dermatology, Saiseikai Izuo Hospital, Japan
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Description
<p>A 70-year-old man with malignant lymphoma was subjected to a fourth course of chemotherapy using gemcitabine and cisplatin. During the intravenous infusion of anticancer agents, pain and redness was observed at the site of insertion. The patient was subsequently treated with the strongest topical steroids and topical cooling agents. However, 2 weeks later, the affected area turned yellow, and the histopathological findings revealed skin necrosis of the entire dermis layer. It took two and a half months to cure the lesion. Close attention should be paid to the development of skin necrosis even when irritant anticancer agents such as gemcitabine and cisplatin are administered. </p>
Journal
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- Internal Medicine
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Internal Medicine 57 (5), 757-760, 2018
The Japanese Society of Internal Medicine
