Successful Treatment of Behcet's Disease Associated with Acute Myeloid Leukemia with Myelodysplasia-related Changes Using Azacitidine and Tacrolimus before Allogeneic Hematopoietic Stem Cell Transplantation
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- Nakamura Yukinori
- Third Department of Internal Medicine, Yamaguchi University School of Medicine, Japan
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- Matsuguma Masafumi
- Third Department of Internal Medicine, Yamaguchi University School of Medicine, Japan
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- Tokunaga Yoshihiro
- Third Department of Internal Medicine, Yamaguchi University School of Medicine, Japan
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- Yamamoto Kaoru
- Third Department of Internal Medicine, Yamaguchi University School of Medicine, Japan
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- Tanaka Mayumi
- Third Department of Internal Medicine, Yamaguchi University School of Medicine, Japan
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- Tanaka Yoshinori
- Third Department of Internal Medicine, Yamaguchi University School of Medicine, Japan
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- Yujiri Toshiaki
- Third Department of Internal Medicine, Yamaguchi University School of Medicine, Japan
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- Tanizawa Yukio
- Third Department of Internal Medicine, Yamaguchi University School of Medicine, Japan
書誌事項
- タイトル別名
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- Successful Treatment of Behçet's Disease Associated with Acute Myeloid Leukemia with Myelodysplasia-related Changes Using Azacitidine and Tacrolimus before Allogeneic Hematopoietic Stem Cell Transplantation
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説明
<p>The coexistence of acute myeloid leukemia (AML) with Behçet's disease (BD) is rare. The optimum treatment for AML-associated BD has not been established. We herein report a patient with BD who developed AML with myelodysplasia-related changes. Induction chemotherapy caused complete remission of the AML but worsened the BD. Thereafter, AML was treated with azacitidine. The BD was steroid-dependent. Tacrolimus was added, which improved the BD. The patient underwent allogeneic hematopoietic stem cell transplantation (HSCT) and remains in complete remission for both diseases. Allogeneic HSCT was found to be a potent therapeutic option for AML-associated BD. In addition, azacitidine and tacrolimus were shown to be a suitable bridging regimen before HSCT. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 56 (10), 1199-1202, 2017
一般社団法人 日本内科学会