[Updated on Apr. 18] Integration of CiNii Articles into CiNii Research

Intravascular Synovial Sarcoma of the Pulmonary Artery with Massive Pleural Effusion: Report of a Case with a Favorable Response to Ifosfamide Chemotherapy and Palliative Radiation Therapy

  • Maekura Toshiya
    Department of Internal Medicine, National Hospital Organization Kinki-chuo Chest Medical Center, Japan
  • Shimizu Shigeki
    Department of Laboratory Medicine and Pathology, National Hospital Organization Kinki-chuo Chest Medical Center, Japan
  • Kawaguchi Tomoya
    Department of Internal Medicine, National Hospital Organization Kinki-chuo Chest Medical Center, Japan Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Japan
  • Morimoto Masahiro
    Department of Radiation Oncology, National Hospital Organization Kinki-chuo Chest Medical Center, Japan
  • Okuma Tomohisa
    Department of Radiology, National Hospital Organization Kinki-chuo Chest Medical Center, Japan Department of Radiology, Graduate School of Medicine, Osaka City University, Japan
  • Matsui Hideo
    Division of Cardiology, National Hospital Organization Kinki-chuo Chest Medical Center, Japan
  • Atagi Shinji
    Department of Internal Medicine, National Hospital Organization Kinki-chuo Chest Medical Center, Japan

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Abstract

Synovial sarcoma (SS) commonly arises in the para-articular soft tissue; however, very few cases of intravascular SS have so far been reported. We herein describe a case of pulmonary artery SS with massive pleural effusion. A biopsy of the pleural lesions showed uniform short spindle cell proliferation, while the SYT-SSX fusion gene, which is preceded by chromosomal translocation t(X;18)(p11;q11), was detected using reverse transcription-polymerase chain reaction. Treatment with ifosfamide chemotherapy and palliative radiation therapy was effective in reducing the growth of the tumor in the pulmonary artery and pleural lesions, indicating that this regimen may be useful for the treatment of unresectable SS in the pulmonary artery.<br>

Journal

  • Internal Medicine

    Internal Medicine 54 (9), 1095-1098, 2015

    The Japanese Society of Internal Medicine

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