Toxicity of New Organophosphorous Insecticides

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  • 新有機燐農薬の毒性
  • シン ユウキ リン ノウヤク ノ ドクセイ

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The toxicity of Diazinon, Chlorthion and Sumicide are studied in comparison with parathion<br>The approximate LD50 for rabbit are (mg per kg of weight)<br>By the application of these compound, the changes are as follows;<br>1) Blood cholinesterase of rabbit, both serum and blood corpuscle, are similarly inhibited as the case of Parathion.<br>2) Symptom of poisoning with rabbit is the same as Parathion.<br>3) By the rabbit, there occur leucocytosis, mainly due to pseudoeosinophils, and the Arneth count is deflected to the left. Lymphocyte shows relative decrease.<br>4) Frog heart is examined by Staub-Fühner method. Heart block that can be made by over 10-8 concentration of Parathion, also occurs by 10-7 Diazinon and 10-6 Chlorthion.<br>5) The blood vessels of rabbit ear are dilated by the application of 0.1mg Diazinon.<br>6) Diazinon and Chlorthion make the lowering of arterial blood pressure in the experiment with dog.<br>7) By the subcutaneous application of these compound the rabbit serum protein and albumin increase, and gamma-globulin decreases.

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