環境汚物(重金属など)の生体膜に対する作用 第1報 各種重金属イオンのミトコンドリア膜に対する作用,特にK<sup>+</sup>区画性について

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  • The effects of various heavy metal ions (such as Hg<sup>2+</sup>, Cd<sup>2+</sup>, Cu<sup>2+</sup> and Zn<sup>2+</sup>) on mitochondrial membrane with specific reference to K<sup>+</sup> compart mentation
  • 環境汚染物質(重金属など)の生体膜に対する作用-1-各種重金属イオンのミトコンドリア膜に対する作用,特にK+区画性について
  • カンキョウ オセン ブッシツ ジュウキンゾク ナド ノ セイタイ マク ニ タ

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The effects of various heavy metal ions such as Hg2+, Cd2+, Cu2+ and Zn2+ on mitochondrial membrane were investigated and the following results were obtained;<br>1) Hg2+, Cd2+, Cu2+ and Zn2+ released the potassium ion from the mitochondria with the increasing level of an affinity to SH compounds.<br>2) The release of K+ by Cd2+ and Zn2+ was inhibited in the presence of Mg2+, but the release of K+ by Hg2+ and Cu2+ was not affected.<br>3) In the presence of ImM DTT, the release of K+ by all of these metal ions was completely inhibited.<br>4) The K+ release by Hg2+ and Cu2+ was inhibited by DTNB or PCMB which bound prefencially the thiol component of membrane protein, but the release by Cd2+ and Zn2+ was not inhibited by these reagents.<br>5) The release of K+ decoupled the oxidative phosphorylation by treatment of the heavy metal ions.

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