Endocrinological study on Sheehan's syndrome

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  • ASAOKA Katsushi
    The Third Department of Internal Medicine, Okayama University Medical School

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Other Title
  • Sheehan症候群の内分泌学的検討
  • Sheehan ショウコウグン ノ ナイブンピガクテキ ケントウ

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The clinical history, laboratory data, and hypothalamic-pituitary-axis were investigated in 8 patients with Sheehan's syndrome.<br>2 patients had panhypopituitarism while 6 patients had selective pituitary deficiencies.<br>Hypothalamic-pituitary-adrenal-axis in 2 patients with Sheehan's syndrome was impaired when the response to metopirone, but not to insulin-induced hypoglycemia.<br>The interpretation of this difference is complicated in secondary hypothyroidism, and better preserved in the response to metopirone than to insulin-induced-hypoglycemia.<br>The imbalance of LH and FSH response to LHRH in 2 cases (a blunted LH response in the presence of normal FSH response) may account for the complication of secondary hypothyroidism.<br>The variety of Sheehan's syndrome was observed, for example that one case without history of postpartum hemorrhage or shock, and others with pregnancy after onset of Sheehan's syndrome.<br>The duration of illness at the time of diagnosis ranged from 1.5 years to 11 years with an average of 6.5 years.<br>In the future, a follow-up investigation of women with the history of postpartum hemorrhage or shock is necessary.

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