溶連菌剤の腫瘍免疫学的研究

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タイトル別名
  • Immunological studies of the streptococcal preparation, OK-432, on neoplasm
  • 溶連菌剤の腫瘍免疫学的研究-3-溶連菌製剤OK-432とBCGの宿主に及ぼす影響と抗腫瘍効果の比較検討
  • ヨウレンキンザイ ノ シュヨウ メンエキガクテキ ケンキュウ 3 ヨウレンキン
  • 第3編 溶連菌製剤OK-432とBCGの宿主に及ぼす影響と抗腫瘍効果の比較検討
  • Part III. Comparative studies on the effect for the host and the antitumor action of the streptococcal preparation, OK-432, and Bacillus Calmette Guérin

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Effect for the host and the tumor of the streptococcal preparation, OK-432, and Bacillus Calmette Guérin (B. C. G.) were comparatively studied.<br>Its results are described below:<br>1) Granulomatous hepatitis with giant cells was observed in 4 of 5 mice (80%) receiving 5×107 B. C. G. organisms by i.p. injection. But there are no pathological findings in liver receiving the same bacterial counts of OK-432 as those of B. C. G..<br>2) Neutrophilia in mice receiving 4×105 B. C. G. organisms i.p. is more remarkable than in mice receiving i.p. OK-432 containing 5×107 streptococcal hemolyticus.<br>3) By administrating OK-432 or B. C. G. i.p. at the same quantity mentioned above, peritoneal cells, particularly macrophages and neutrophils, are exudated more markedly in mice receiving OK-432 than B. C. G..<br>4) At the same dosage, the survival rate of the C3H mice pretreated i.p. with OK-432 was more prolonged than the rate of the C3H mice pretreated i.p. inoculation of methylcholanthrene-induced sarcoma.<br>The results stated above lead to the conclusions that B. C. G. has a liver damage, i.e., granulomatous hepatitis as the side effect by administrating the massive dose in contrast to OK-432. B. C. G. is stronger than OK-432 as the general stimulant to the host, and OK-432 is stronger than B. C. G. as the local stimulant. And consequently the host-mediated antitumor action of OK-432 is more predominant than B. C. G. at the dose that the author investigated in this paper.

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